FtpWebRequest request = (FtpWebRequest)WebRequest.Create(ftpUrl);
    request.Credentials = new NetworkCredential(userName,password);

    request.EnableSsl = true;
    //ServicePointManager.ServerCertificateValidationCallback = ServicePointManager_ServerCertificateValidationCallback;

    X509Certificate cert = X509Certificate.CreateFromCertFile(@"C:\MyCertDir\MyCertFile.cer");
    X509CertificateCollection certCollection = new X509CertificateCollection();
    certCollection.Add(cert);

    request.ClientCertificates = certCollection;

此外,如果证书生成异常有问题,您可能需要实现自己的证书验证回调方法与ServicePointManager.ServerCertificateValidationCallback Property一起使用.这可以像始终返回true一样简单,或者像我用于调试的一样复杂：

public static bool ServicePointManager_ServerCertificateValidationCallback(object sender,X509Certificate certificate,X509Chain chain,SslPolicyErrors sslPolicyErrors)
    {
        bool allowCertificate = true;

        if (sslPolicyErrors != SslPolicyErrors.None)
        {
            Console.WriteLine("Accepting the certificate with errors:");
            if ((sslPolicyErrors & SslPolicyErrors.RemoteCertificateNameMismatch) == SslPolicyErrors.RemoteCertificateNameMismatch)
            {
                Console.WriteLine("\tThe certificate subject {0} does not match.",certificate.Subject);
            }

            if ((sslPolicyErrors & SslPolicyErrors.RemoteCertificateChainErrors) == SslPolicyErrors.RemoteCertificateChainErrors)
            {
                Console.WriteLine("\tThe certificate chain has the following errors:");
                foreach (X509ChainStatus chainStatus in chain.ChainStatus)
                {
                    Console.WriteLine("\t\t{0}",chainStatus.StatusInformation);

                    if (chainStatus.Status == X509ChainStatusFlags.Revoked)
                    {
                        allowCertificate = false;
                    }
                }
            }

            if ((sslPolicyErrors & SslPolicyErrors.RemoteCertificateNotAvailable) == SslPolicyErrors.RemoteCertificateNotAvailable)
            {
                Console.WriteLine("No certificate available.");
                allowCertificate = false;
            }

            Console.WriteLine();
        }

        return allowCertificate;
    }