Public Const WM_HOTKEY = &H312
Public Const MOD_ALT = &H1
Public Const MOD_CONTROL = &H2
Public Const MOD_SHIFT = &H4
Public Const GWL_WNDPROC = (-4)

Public Declare Auto Function RegisterHotKey Lib "user32.dll" Alias _
"RegisterHotKey" (ByVal hwnd As IntPtr,ByVal id As Integer,ByVal fsModifiers As Integer,ByVal vk As Integer) As Boolean

Public Declare Auto Function UnRegisterHotKey Lib "user32.dll" Alias _
"UnregisterHotKey" (ByVal hwnd As IntPtr,ByVal id As Integer) As Boolean

Private Sub Form1_Load(ByVal sender As System.Object,ByVal e As System.EventArgs) Handles MyBase.Load
'注册全局热键
RegisterHotKey(Handle,MOD_CONTROL,Asc("T")) '第一个热键 Ctrl+T
RegisterHotKey(Handle,1,Nothing,Keys.F4) '第二个热键 F4
End Sub

Private Sub Form1_FormClosed(ByVal sender As System.Object,ByVal e As System.Windows.Forms.FormClosedEventArgs) Handles MyBase.FormClosed
'注销全局热键
UnRegisterHotKey(Handle,0)
UnRegisterHotKey(Handle,1)
End Sub

Protected Overrides Sub WndProc(ByRef m As Message)If m.Msg = WM_HOTKEY ThenMsgBox("在这里添加你要执行的代码",MsgBoxStyle.Information,"全局热键")End IfMyBase.WndProc(m)End SubEnd Clas