//Get the assembly informationSystem.Reflection.Assembly
assemblyInfo = System.Reflection.Assembly.GetExecutingAssembly();

//Location is where the assembly is run from 
string assemblyLocation = assemblyInfo.Location;

//CodeBase is the location of the ClickOnce deployment files
Uri uriCodeBase = new Uri(assemblyInfo.CodeBase);
string ClickOnceLocation = Path.GetDirectoryName(uriCodeBase.LocalPath.ToString());